LIN28A and Other metabolic disease: Lin28, a highly conserved RNA-binding protein first identified in Cryptobacterium hidradenum in 2000 [32], is a core stem cell factor that regulates the biogenesis of embryonic stem cells and various cancer cell lines in a pleiotropic manner [26], reprograms translation to promote the progression of various metabolic diseases and cancers, and plays a regulatory role in the transcriptional regulation of let-7 [16].