RRM2 and colorectal carcinoma: Four downregulated DEGs (IGF2BP3, PHF19, FUT11 and C2orf48) and four upregulated DEGs (IL1B, GPA33, PPP1R14C and UGT2B7) were observed in P53R and RKO cells following combinational therapy, and IGF2BP3, PHF19, C2orf48, IL1B, GPA33, PPP1R14C and UGT2B7 were overexpressed in CRC TCGA cohort (Supplementary Fig. 6).