PFKFB3 and Hepatic fibrosis: An outstanding issue, however, is that dysregulation of multiple glycolytic genes, including pyruvate kinase M2 (PKM2) [39], hexokinase 2 (HK2) [33], and fructose-2,6-bisphosphatase-3 (PFKFB3) [7], has been identified in liver fibrosis, which complicates understanding the relationship between liver fibrosis and glycolysis.