ACTA2 and Hepatic fibrosis: In a correlation study between IGF2BP2 and representative markers of liver fibrosis, based on cirrhotic samples (n = 40) from the GSE25097 dataset, ACTA2 (actin alpha 2) expression and collagen alpha 1 (COL1α1) expression both exhibited a substantial positive correlation with IGF2BP2 expression (Fig. 1C, D.