In analyzing B cells in the tumor microenvironment, B cells were separated into two clusters: one termed as follicular B cell, with high expressions of MS4A1, CD79B, CD52, and another termed as plasma cell, with high expressions of IGHG1, IGHG4 and MZB1 (Supplementary Fig. 8). The gene discussed is IGHG4; the disease is neoplasm.