DUSP1_fib highly expressed DUSP1 (Supplementary Fig. 4b), which was a gene highly expressed in tumor cells, showing drug resistance in multiple tumors, including gefitinib resistance in non-small cell lung cancer, apatinib resistance in gastric cancer, paclitaxel resistance in ovarian cancer, gemcitabine resistance in gallbladder carcinoma, etc [28–31]. This evidence concerns the gene DUSP1 and gallbladder carcinoma.