Based on the analysis on single-cell data, the tumor cells can be divided into six categories, i.e., PDGFRA_fib, BASP1_fib, DUSP1_fib, IDO1_fib, KITlow DOG+ SMA+_fib, and KIT-_fib, of which BASP1_fib and DUSP1_fib are the most common cell subpopulations in GIST (Fig. 3). This evidence concerns the gene KIT and neoplasm.