TP53 and gastrointestinal stromal tumor: In this imatinib-resistant group, the Receptor Tyrosine Kinases, p53 pathway, PTEN pathway, WNT pathway, NOTCH pathway, and cell death pathway were more significantly enriched in up-regulated genes of BASP1_fib and DUSP1_fib (Supplementary Fig. 5a), but in down-regulated genes of PDGFRA_fib, IDO1_fib, and KITlow DOG+ SMA+_fib (Supplementary Fig. 5b), which indicated that the drug-resistance mechanism varied with different cell subpopulations in GIST.