To investigate whether LDHA could be delivered from macrophages into glioblastoma cells via EVs, we treated EMφ with GW4869 (an EV biogenesis and release inhibitor) and found that this treatment abolished EMφ CM-induced LDHA upregulation in both CT2A and GL261 cells (Fig. 5c, d). The gene discussed is LDHA; the disease is glioblastoma.