On the histological level, immunofluorescence for Ki67 and cleaved caspase 3 (CC3) demonstrated that glioblastoma cell proliferation was dramatically reduced, whereas apoptosis was increased upon Ldha depletion (Supplementary Fig. S14a–d) and treatment with stiripentol and isosafrole (Supplementary Fig. S14e–h). This evidence concerns the gene MKI67 and glioblastoma.