To further investigate whether LDHA-regulated lactate contributes to this process, we treated LDHA-depleted glioblastoma cells with lactate and found that this treatment rescued the impaired signaling of P-ERK, YAP1, P-STAT3, CCL2, and CCL7 in shLdha CT2A cells (Supplementary Fig. S7q–s). This evidence concerns the gene STAT3 and glioblastoma.