To determine the molecular basis of tumor glycolysis in support of macrophage infiltration, we examined the connection between the expression of key glycolysis and tricarboxylic acid (TCA) cycle enzymes (e.g., HK1, HK2, HK3, PGM1, PGM2, LDHA, LDHB, MDH1, MDH2, FH, SDHA, SUCLA2, OGDH, IDH3A, IDH3B, IDH3G, CS, and ACO1) with patient survival, immune score, and macrophage signature in TCGA glioblastoma patient tumors. This evidence concerns the gene MDH2 and neoplasm.