CASP3 and glioblastoma: On the histological level, immunofluorescence for Ki67 and cleaved caspase 3 (CC3) demonstrated that glioblastoma cell proliferation was dramatically reduced, whereas apoptosis was increased upon Ldha depletion (Supplementary Fig. S14a–d) and treatment with stiripentol and isosafrole (Supplementary Fig. S14e–h).