LDHA and glioblastoma: To further confirm the relevance of LDHA-mediated tumor glycolysis in promoting macrophage infiltration, we conducted shRNA-mediated LDHA depletion (shLdha) in glioblastoma cells, such as CT2A and GL261 (Fig. 2d), or treated them and GSCs with LDHA inhibitors (e.g., stiripentol and FX11).