Of the 1,218 PCAWG patients, 28 had tumors harboring somatic SV breakpoints within ATRX (spanning multiple cancer types), and an additional four patients (two breast cancer and two uterine cancer) had germline SV breakpoints within ATRX, with ATRX expression notably lower in tumors from both patient groups (Figure 5B). Here, ATRX is linked to breast carcinoma.