As the biomarker of the Cluster 1 subtype and the predictor of poor survival, the Simplexvirus, Pestivirus, Marichromatium, Pararhodospirillum, Acidibacillus, Candidatus Pelagibacter, Alcanivorax, Succinimonas, Oceanospirillum, and Roseivirga were negatively correlated with the anti-tumor immune cells, including NK cells and CD4 and CD8 cells. This evidence concerns the gene CD8A and neoplasm.