Our P. aeruginosa collection (25), including different profiles of antibiotic resistance and epidemic clones from both acute (ST111, ST175, and ST244) and cystic fibrosis (ST146 and ST274) contexts (40), added a key interesting point to previous studies: investigating whether adaptation to chronic infection could entail consequences for susceptibility to HNP-1 or hBD-3 defensins. Here, DEFA1 is linked to cystic fibrosis.