Tamoxifen treatment in CD93–/iECKO resulted in an improved CD93 gene deletion in the retina vasculature and an up to 75% decrease in CD93 expression in HCmel12 tumor vessels in CD93–/iECKO mice (Supplemental Figure 7, A and B, and Figure 4, A and B, respectively). The gene discussed is CD93; the disease is neoplasm.