Consistent with the in vitro results above, transfer of Lip-1 ex vivo–treated 2C CD8+ T cells significantly inhibited tumor growth in B16-SIY–bearing mice (Supplemental Figure 2, A–C) accompanied by an increased accumulation and effector function of transferred CD8+ T cells within tumors (Supplemental Figure 2, D–H). This evidence concerns the gene CD8A and neoplasm.