These findings were obtained in both in vitro and in vivo models AT1R-overexpressing breast cancer, but not in AT1Rlow cell line.114 Nevertheless, contradictory results were obtained by a number of in vitro and in vivo studies demonstrating no or less anti-cancer effects of ARBs, mostly using losartan or irbesartan99,115–127 (see Supplementary data online, Table S3). The gene discussed is AGTR1; the disease is cancer.