Both the percentage of men (from 51.2 to 56.3%) and mean age (from 66.1 ± 11.0 to 67.9 ± 13.1 years) progressively increased, from the first to the last quinquennium, while T2D duration at the time of starting fast-acting insulin progressively decreased overtime (from 14.5 ± 9.3 to 10.4 ± 8.5 years). Here, INS is linked to type 2 diabetes mellitus.