INS and obesity due to melanocortin 4 receptor deficiency: In the group of T2D subjects starting fast-acting insulin in add on to basal insulin, there was an overall improvement overtime of major risk factors; however, mean body weight (80.4 ± 17.5 kg) and BMI (29.9 ± 9.1 kg/m2) values, close to the cut-off for the diagnosis of obesity, remained almost constant in the three 5-year periods under examination (Table 3).