On the other hand, the overall stable rate of prescription of insulin therapy in T2D subjects overtime (~ 30% of T2D subjects) [8], despite the variety of currently available therapeutic options, should be related to the progressive nature of the disease, and the occurrence of beta cell dysfunction and deterioration of glucose control, especially in those with longer diabetes duration, higher baseline HbA1c and glucose levels, as well as with increased lipid, inflammatory and beta-cell dysfunction markers or those on a combination of metformin plus secretagogues [13, 14]. Here, INS is linked to diabetes mellitus.