Another longitudinal study observing potential associations between imaging alterations and progranulin level in FTD patients revealed that patients with progranulin mutations reflect a faster rate of whole-brain atrophy and there is a significant correlation between the progranulin level and asymmetric atrophies in the inferior frontal, temporal, and inferior parietal lobe of gray matter [38]. The gene discussed is GRN; the disease is frontotemporal dementia.