As such, MYD88 L265P mutation may be the fortuitous finding of other lymphoproliferative disorders -such as IgM monoclonal gammopathy of unknown significance (MGUS), lymphoplasmocytic lymphoma/Waldenstrom macroglobulinemia, or DLBCL-, rather than the rare IVLCBL. This evidence concerns the gene CD40LG and diffuse large B-cell lymphoma.