In addition, decreases in the expression levels of ASC, Caspase-1, and IL-1β/IL-18 have been shown to alleviate the cognitive impairment of gerbils after I/R [29], and ASC exacerbates ischemic neurological deficits and inflammatory reactions in an NLRP3-dependent manner. The gene discussed is CASP1; the disease is Cognitive impairment.