The results showed that the protein expression levels of p-Syk (0.24 ± 0.11; 2.82 ± 0.34; 1.03 ± 0.27), gp91phox (0.26 ± 0.12; 2.72 ± 0.31; 1.05 ± 0.22), p47phox (0.29 ± 0.13; 2.88 ± 0.37; 0.97 ± 0.25) and p22phox (0.28 ± 0.14; 2.78 ± 0.35; 1.01 ± 0.23) in the CCH group and the probucol group were significantly increased compared with the sham group. This evidence concerns the gene NCF1 and columnar cell hyperplasia of the breast.