The results revealed that compared with sham group, CCH group and probucol group exhibited increased levels of IL-1β (0.32 ± 0.13; 2.60 ± 0.24; 1.03 ± 0.23), IL-18 (0.24 ± 0.12; 2.68 ± 0.25; 1.03 ± 0.25), and pyroptosis-associated inflammasome proteins (NLRP3 (0.38 ± 0.10; 2.97 ± 0.37; 1.12 ± 0.23), ASC (0.37 ± 0.14; 2.98 ± 0.35; 0.95 ± 0.22), and Caspase-1 (0.29 ± 0.15; 2.96 ± 0.30; 1.02 ± 0.23)). This evidence concerns the gene CASP1 and columnar cell hyperplasia of the breast.