As shown in Figure 5A, 5B, compared with the sham group, the expression levels of Bax (0.21 ± 0.11; 2.72 ± 0.33; 0.92 ± 0.27); (Sham VS CCH, P < 0.01); (CCH VS Probucol, P < 0.01) and Caspase-3 (0.24 ± 0.12; 2.93 ± 0.26; 1.03 ± 0.28) (Sham VS CCH, P < 0.01); (CCH VS Probucol, P < 0.01) were increased in the CCH group and the probucol group, while the expression level of Bcl-2 (2.93 ± 0.30; 0.21 ± 0.13; 1.14 ± 0.23); (Sham VS CCH, P < 0.01); (CCH VS Probucol, P < 0.01) was decreased. This evidence concerns the gene CASP3 and columnar cell hyperplasia of the breast.