Based on bioinformatics analysis and survival data of prostate cancer patients from TCGA and GEO cohorts, a prognostic model was constructed using 9 genes (MYLK, FBLN1, PTGDS, TGFB1, MXRA8, PTN, COL1A1, THBS2, and MT1E), which was validated by clinical prognosis and correlation with tumor immunity. This evidence concerns the gene TGFB1 and Familial prostate cancer.