Studies have shown that radiation therapy can contribute to the formation of an immunosuppressive tumor microenvironment (TME) by promoting the infiltration of M2 macrophages, increasing the number of regulatory T cells, impairing the function of CD8 + T lymphocytes, and inducing the release of immunosuppressive cytokines (Shevtsov et al., 2019). The gene discussed is CD8A; the disease is neoplasm.