Taken together with the present study, we have shown that multiple sRNAs are present in OMVs, including the 35 nt tRNA-Met halves identified in the present study and the 24 nt sRNA sRNA52320 that are capable of selectively downregulating IL-8/KC levels in mice BALF and IL-8 and IP-10 secreted by CF-HBEC. This evidence concerns the gene CALCA and cystic fibrosis.