TNFRSF4 and hepatocellular carcinoma: Despite the association of OX40 to more aggressive disease in HCC, Treg, Th, and CTL in HCC-derived TILs can be skewed to the pro-inflammatory state upon multimerisation of OX40 using a hexameric OX40 ligand or bead-bound or Fc-engineered OX40 antibody in vitro.