CD40 and diffuse large B-cell lymphoma: Other phase I and II trials on dacetuzumab in patients with multiple myeloma (MM) and diffuse large B-cell lymphoma (DLBCL), or on ChiLob7/4 (chimeric agonistic CD40 IgG1 mAb) in DLBCL patients have shown a similar safety profile as well as modest clinical activity (188–190).