Through GSEA analysis of CD274-associated signaling pathways (Figures 5D–I), it was revealed that the primary enriched pathways were the chemokine signaling pathway, cytokine-cytokine receptor interaction, JAK-STAT signaling pathway, cytosolic-DNA sensing pathway, primary immunodeficiency, and the adipocytokine signaling pathway. The gene discussed is CD274; the disease is inborn error of immunity.