Poor prognostic factors in primary PCL include both clinical and laboratoryparameters.6,7 Of these, the case study patient presented with aperformance status score of ≥ 2, an absolute peripheral blood plasma cell count of> 4 × 109/L, thrombocytopenia, diffuse marrow infiltration,specific cytogenetic abnormalities, including a complex karyotype, elevated lactatedehydrogenase, elevated β2 microglobulin and hypercalcaemia. This evidence concerns the gene HLA-G and Hypercalcemia.