TET2 and acute myeloid leukemia: It was elegantly evidenced in MPNs with TET2 and JAK2 mutations that type of mutations and their order determines the kinetics of neoplasm development (144, 145) The precedence of the “landscaping” mutation over the signaling/proliferative mutation (the scenario characteristic for AML) was associated with older age of patients than when the mutation order was reverse (Figure 4).