It was shown that different endothelial cells, i.e., lymphatic endothelial cells or glomerular endothelial cells express F8 (Pan et al., 2016) but an increment in levels of F8 was observed in hemophilia patients after liver transplantation leading to the fact that the main contributor of plasma F8 is the liver (Marchioro et al., 1969; Bontempo et al., 1987). The gene discussed is F8; the disease is hemophilia.