IL6 and non-small cell lung carcinoma: Silencing hsa_circ_0000190 resulted in pronounced IL-6 downregulation in both DDP-resistant cell lines, and this effect was counteracted by miR-1253 inhibitor treatment (Figures 5(h) and 5(i)), highlighting the ability of hsa_circ_0000190 to function as a molecular sponge for miR-1253 that promotes IL-6 upregulation in chemoresistant NSCLC cells.