Prepregnancy maternal BMI is significantly associated with cord blood PCSK9 in neonates born to nonoverweight/nonobese mothers, whereas higher cord blood PCSK9 concentrations are significantly associated with maternal overweight/obesity status, after adjusting for GA, birth weight, sex, and intrauterine growth restriction. This evidence concerns the gene PCSK9 and obesity due to melanocortin 4 receptor deficiency.