In multivariate linear regression analysis, higher cord plasma PCSK9 concentration was significantly associated with maternal overweight/obesity status (b = 50.12; 95% CI, 4.02-96.22; P = .033) after adjusting for GA (b = −16.60; 95% CI, −96.22 to −10.02; P = .219), birth weight (b = −0.01; 95% CI, −0.05 to −0.04; P = .963), male sex (b = −8.83; 95% CI, −52.86 to −35.19; P = .692), and intrauterine growth restriction (b = 13.45; 95% CI, −70.32 to −97.24; P = .751) (Table 4). Here, PCSK9 is linked to obesity due to melanocortin 4 receptor deficiency.