A positive correlation was observed between the cognitive impairment and age (p < 0.001), history of hypertension (p < 0.001), HHcy (p < 0.001), MTHFR genotype (p < 0.001), WMH (p < 0.001) and lacunes (p = 0.01). The gene discussed is MTHFR; the disease is Hypertension.