These suggest the specific role of DLST as a downstream target of EPC1 and EPC2 in regulating HSPC proliferation, which may widen the role of DLST besides its role in MYC-mediated leukemogenesis32 and neuroblastoma,33 and also widen the roles of EPC1 and EPC2 in regulating HSPC development via DLST related mitochondria metabolism. The gene discussed is EPC2; the disease is neuroblastoma.