In the present study, we found that SOCS5 and SOCS6 are downstream targets of miR-424-5p, and miR-424-5p activated JAK2/STAT3 and PI3K/AKT pathways in NSCLC by targeting down-regulation of SOCS5 and SOCS6. Here, SOCS5 is linked to non-small cell lung carcinoma.