A study by Tung et al [14] reported that among sequential patients with breast cancer (n = 488) from the USA, germline variants in cancer predisposition genes were found in 10.7%, using a panel of 25 predisposition genes including 6.1% in BRCA1/2 and 4.6% in other breast/ovarian cancer predisposition genes including CHEK2 (n = 10), ATM (n = 4), BRIP1 (n = 4) and one each in PALB2, PTEN, NBN, RAD51C, RAD51D, MSH6 and PMS2. This evidence concerns the gene MSH6 and breast cancer.