Reduced CDX2 in a human colon cancer cell line has been demonstrated to enhance NF-κB-mediated inflammatory response, upregulating the expression of cyclooxygenase 2 (COX2) protein, encoded by the prostaglandin (PG)-endoperoxide synthase 2 (PTGS2) gene (1q31.1; OMIM #600262). The gene discussed is PTGS2; the disease is malignant colon neoplasm.