Levels of serum biochemical indices ALT, AST and TBil, representing liver functions, showed significant increases in the WT group 6 h after liver failure establishment, while the THBS1KO group measurements were significantly lower (P < 0.0001) and gradually returned to near-normal levels at 24 h following drugs administration (Fig. 5C-E). This evidence concerns the gene GPT and Hepatic failure.