Moreover, MUC20 overexpression blocked the interaction between MET and CDKN2A in PI-resistant KAS-6/1 and U266 cells (Fig. 5B and Supplementary Figure S8B), indicating that MUC20 disrupted the interaction of MET and CDKN2A by binding with MET in PI-resistant MM cells. This evidence concerns the gene CDKN2A and Miyoshi myopathy.