More importantly, CDKN2A overexpression via transfection with a lentiviral vector carrying CDKN2A (Supplementary Figure S4B) decreased FDX1 protein levels in PI-resistant KAS-6/1 and U266 cells (Supplementary Figure S5B), suggesting that CDKN2A might suppress cuproptosis by downregulating FDX1 in PI-resistant MM cells. The gene discussed is FDX1; the disease is Miyoshi myopathy.