TP53 and Miyoshi myopathy: In addition, KEGG pathway enrichment analysis showed that upregulated DEED-amplified encoding genes of PI-resistant MM cells were involved in the TGF-beta and p53 signaling pathways (Supplementary Figure S15B); however, the downregulated DEED-amplified encoding genes of PI-resistant MM cells were involved in the platinum drug resistance and PPAR signaling pathways (Supplementary Figure S15B).