Cellular neighbourhoods analysis indicated that both macrophages (p = 0.003) and effector CD4<sup>+</sup> T cells (p = 0.01) in mixed tumour neighbourhoods, as well as CD8<sup>+</sup> T cells (p = 0.03) in HLADR<sup>+</sup> tumour neighbourhoods were associated with favorable clinical response. This evidence concerns the gene CD4 and neoplasm.