There were no significant differences in histologic type between users and non-users of SNS-AH, diuretics, CCBs and ACE inhibitors, whereas serous adenocarcinoma was more frequent among BBs users (72% of users vs. 58% of non-users, p = 0.006) and ARB users (68% of users vs. 61% of non-users, p = 0.012). The gene discussed is ACE; the disease is serous adenocarcinoma.