In KIRC, BAX was predominantly expressed in malignant tumor cells, CD8 T cells, NK cells, and monocytes, CASP1 was predominantly expressed in monocytes and macrophages, CASP8 was highly expressed predominantly in CD8 T cells and NK cells, and PYCARD was predominantly expressed in monocytes and macrophages (Figure S1A-E). The gene discussed is CASP1; the disease is cancer.