In this study, we first analyzed three common renal cell carcinoma subtypes (KIRC, KIRP, and KICH) for the occurrence of PANoptosis in their tumor microenvironment and constructed a PANoptosis signature based on PANoptosis-related genes (BAX, CASP1, CASP8, and PYCARD) and derived a new metric, the The PANoptosis Immunity Index (PANII) can reflect the characteristics of PANoptosis in KIRC, KIRP and KICH, and among the three renal cell carcinoma subtypes mentioned above, the group with high PANII showed a “hot” tumor microenvironment, i.e., it was more effective for immunotherapy. This evidence concerns the gene CASP8 and renal cell carcinoma.