caspases exist as inactive zymogens on conserved protein hydrolytic processing on conserved aspartic acid residues, generating two subunits of size that dimerize to form the active enzyme, a process that has been shown to play an important role in the induction of apoptosis, especially Caspase-8 A key protein of cross-talk signal way in “PANoptosis " in cancer [8, 31–33]. The gene discussed is CASP8; the disease is cancer.