To further characterize the immune microenvironment of three common renal cell carcinoma subtypes (KIRC, KIRP and KICH) based on PANoptosis, we constructed PANoptosis by principal component analysis (PCA) based on the PANoptosis genes obtained from the above analysis, including BAX, CASP1, CASP8, and PYCARD characterization and derived a new index, the PANoptosis immunity index (PANII). Here, CASP8 is linked to hereditary clear cell renal cell carcinoma.