For example, consider a CRC patient with the tumor originating in the rectum (60 points), N staging in CT as N0 (0 points), gross tumor type as ulcerative (22 points), low tumor differentiation (100 points), carcinoembryonic antigen (CEA) positive (60 points), and a platelet-to-lymphocyte ratio (PLR) > 136.98 (39 points), culminating in a total of 281 points. Here, CEACAM5 is linked to neoplasm.