CEACAM5 and colorectal cancer: However, noteworthy distinctions (p < 0.05) emerged between these two groups in terms of T-stage and N-stage in CT, tumor histological differentiation (grading), tumor macroscopic type, tumor primary location, carcinoembryonic antigen (CEA), carbohydrate antigen CA199 (CA199), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).Multivariate logistic regression analysis identified six clinical and pathological characteristics as independent risk factors for perineural invasion (PNI) in patients with colorectal cancer (CRC).