However, noteworthy distinctions (p < 0.05) emerged between these two groups in terms of T-stage and N-stage in CT, tumor histological differentiation (grading), tumor macroscopic type, tumor primary location, carcinoembryonic antigen (CEA), carbohydrate antigen CA199 (CA199), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).Multivariate logistic regression analysis identified six clinical and pathological characteristics as independent risk factors for perineural invasion (PNI) in patients with colorectal cancer (CRC). This evidence concerns the gene CEACAM5 and colorectal carcinoma.