Since the MMPs/TIMPs ratio seems to provide a better measurement of proteolytic activity, and the effectiveness of resistance training in modulating BBB permeability in MS patients is unknown as well as the widespread prevalence of this disease in women compared to men; we hypothesized that a 12-week resistance training (RT) has effect on serum levels of S100B, MMP-2, 9, TIMP-1, 2, and cognitive performance with MS women (MS-W). The gene discussed is TIMP1; the disease is myeloid sarcoma.