In the univariate analysis, we found that tumor size greater than 2 cm (HR = 1.569, 95% CI = 1.062–2.318, P = 0.024), poorly differentiated tumor (HR = 1.449, 95% CI = 1.023–2.054, P = 0.037), vascular invasion (HR = 1.962, 95% CI = 1.441–2.728, P < 0.001), p53 positivity (HR = 1.563, 95% CI = 1.131–2.157, P = 0.007), and submucosal tumor infiltration (HR = 1.274, 95% CI = 1.033–1.571, P = 0.024) were significantly associated with patient survival time. The gene discussed is TP53; the disease is neoplasm.