TP53 and neoplasm: In the multivariate model, poorly differentiated tumor (HR = 1.514, 95% CI = 1.142–2.134, P = 0.021), vascular invasion (HR = 1.778, 95% CI = 1.389–2.633, P < 0.001), p53 positivity (HR = 1.801, 95% CI = 0.907–2.243, P = 0.062), and submucosal tumor infiltration (HR = 1.189, 95% CI = 0.968–1.355, P = 0.077) had P values less than 0.05, indicating that they still had significant predictive ability in the multivariate model.