Compared with that in the healthy group, the proportion of C8 (memory CD8 + T cells), C14/C20 (CD8 + NKT cells), C4 (memory CD4 + T cells), and C27 (mast cell) cell subpopulations increased significantly in patients with vitiligo, while the numbers of C26/C12 melanocytes and almost all keratinocyte subpopulations decreased significantly. This evidence concerns the gene CD8A and vitiligo.