To investigate the regulatory mechanism underlying HCC-specific SE-controlled genes related to oxidative stress response, we employed HOMER to analyze the transcription factor-binding motifs of the eight such genes (GPR98, SPIDR, TAT, DHCR24, RHOB, ZFP36L1, MTHFS and MBP). The gene discussed is DHCR24; the disease is hepatocellular carcinoma.