Even though the involvement of IL-17A variants has yet to be fully elucidated, a previous study had shown that IL-17F (rs6913472 and rs4715291) and IL-17RA (rs12159217 and rs41396547) polymorphisms independently modulate susceptibility to Cerebral Malaria and provide evidence that IL-17F protects against it [44]. The gene discussed is IL17F; the disease is cerebral malaria.