In addition, CB2 receptors not only reduce oxidative stress and inflammation, but also regulate mitogen-activated protein kinases (MAPK) and indirectly stimulate phospholipases, including PLA2 [49, 50], which may indicate a feedback loop and further intensification of phospholipid metabolism, as may indicate reduced levels of free PUFAs, especially after co-infection. Here, WNK2 is linked to coinfection.