After adjusting for phenotypes related to anti-diabetic medications, such as drugs used in diabetes (IVW OR = 0.9812; 95% CI: 0.9324, 1.0325; P = 0.4740), diabetes, insulin treatment (IVW OR = 0.9822; 95% CI: 0.9463, 1.0194; P = 0.3380), and Metformin (IVW OR = 1.0000; 95% CI: 0.9825, 1.0178; P = 0.9930), the correlation between T1DM and PD risk was no longer significant. This evidence concerns the gene INS and type 1 diabetes mellitus.