The evidence is suggestive of almost twofold and threefold risk of IUGR in women with systemic sclerosis or coeliac disease (OR 3.20 (2.21–4.53) OR 1.71 (1.36–2.14) respectively) [29, 109, 122], whereas no significant association was observed in women with AxSpA (OR 1.05 (0.24–4.49)), SLE (OR 7.67 (0.32–161.50)), thyroid autoimmunity (TPO) (OR 1.61 (0.23–11.12)) [32, 38, 130]. The gene discussed is TPO; the disease is systemic lupus erythematosus.