For example, upregulation of EGR2 is required for colon cancer stem cells survival and tumor growth18, upregulation of HDAC5 promotes colorectal cancer cell proliferation19, upregulation of SP1 activates the Wnt/β catenin pathway in colorectal cancer20, upregulation of CCND2 in conjunction with JAK2 and STAT3 promotes colorectal cancer stem cell persistence21, upregulation of NANOG modulates stemness in human colorectal cancer22, upregulation of ADGRG1 promotes proliferation of colorectal cancer cells and enhances metastasis via the epithelial-to-mesenchymal transition23. This evidence concerns the gene NANOG and colonic neoplasm.