We found that the top ten most associated transcription factors across colorectal cancer development are ZNF770, SP1, SP2, SP3, PATZ1, MAZ, PAX5, KLF15, WT1 and KLF3. Among these, SP1, WT1, PAX5 and KLF3 are known to be associated with transcriptional misregulation in cancer (hyper-geometric test, Kyoto Encyclopedia of Genes and Genomes (KEGG) database, Odds Ratio = 70.22, FDR < 0.0001). The gene discussed is KLF3; the disease is cancer.