Similar to control (CT) LAFOs (Fig. 5), we successfully generated CDH AFOs from 16 AF samples (16 of 20; 80%) and CDH TF organoids (TFOs) from 7 TF samples (7 of 17; 41.2%; Fig. 6a and Extended Data Figs. 2a and 6a,b). This evidence concerns the gene CHDH and atrial fibrillation.