Tissue DNA sequencing – using an MD Anderson paired tumor-normal next-generation sequencing assay that analyzed 146 cancer-related genes-suggested the presence of short in-frame deletion of RET coding sequence that resulted in four amino acid deletion [NM_020975.6(RET):c.2094_2705del p.D898_E901del] in the RET kinase activation loop in both tissue and plasma samples. The gene discussed is RET; the disease is neoplasm.