In addition, the mechanisms by which SRBD could be associated with hypertension include not only sympathetic nervous system hyperactivity [24], but also increased insulin resistance [25], activation of the Renin-Angiotensin-Aldosterone (RAA) system [26–28], activation of mineralocorticoid receptors [29], oxidative stress [30], and chronic inflammation [31, 32]. This evidence concerns the gene REN and hypertensive disorder.