The major aims of our study are to 1st explore how KCTD15 affects CRC cell growth and apoptosis and whether the HDAC1-p53 pathway is involved; 2nd whether the abnormal expression of KCTD15 in CRC tissues is associated with m6A modification mediated by FTO and YTHDF2. This evidence concerns the gene HDAC1 and colorectal carcinoma.