BH3 profiling also showed ARK1 and ARK2 cells were relatively unprimed given the limited levels of cytochrome c release in response to even very high levels of pro-apoptotic BIM and BID BH3 peptides (10, 30 and 100 μM concentrations), which typically induce full release of cytochrome c in primed cancer cells [42]. The gene discussed is BCL2L11; the disease is cancer.